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Pharmazie in unserer Zeit - Hochleistungsanalytik für die Entwicklung von Biosimilars Nov 2012 468ff Scientific Paper

Bei der Entwicklung eines Biosimilars ist die Ähnlichkeitsanalyse zum Originator für den Erfolg entscheidend. Die Anwendung von Hochleistungsanalytik wie zum Beispiel der Protein-Massenspektrometrie liefert auch für strukturell sehr komplexe Biotherapeutika umfangreiche Daten zu mehreren Hundert Qualitätsattributen und damit die Basis der Vergleichbarkeit.

Cosmetic Scienc“Skin-Omics”: Use of Genomics, Proteomics and Lipidomics to Assess Effects of Low Molecular Weight Scleroglucan Scientific Paper

The stratum corneum, representing the outmost layer of the skin, is a vitally important barrier of the body and protects it from various environmental stress factors. In order to maintain its elasticity, suppleness and barrier function, the skin requires optimal water content. In order to guarantee these functions skin moisture is tightly regulated by two factors, namely by the integrity of the water impermeable barrier of the skin itself and by the content of water-binding substances in the stratum corneum.

Full Antibody Characterization 2008 Poster

In recent years the development of biopharmaceuticals hasincreased enormously and also in the next years an immensegrowth is expected. The production of recombinant antibodies is a challenging field of great commercial value. Changes in the proteinstructure or posttranslational modifications can occur and these canhave negative effects on the function of the protein and on thetherapeutic efficacy. Currently very important modifications oftherapeutic antibodies are glycosylation, deamidation or C-terminalLysine cleavage. We have developed methods for the preciseanalysis of these modifications.…

Increasing the potential of proteome analysis via comparison of proteomic data with protein-protein interaction pathway databases 2007 Poster

Signal transduction is an important biological process conducted by a
variety of protein protein interactions (PPIs) which transduce external
signals into cellular responses. Proteome analysis has the potential to
uncover these mechanisms but has limitations. Membrane receptors,
kinases and transcription factors are normally underrepresented in a typical proteome study but are most interesting targets for drug development. To get access to these protein classes high-confidence PPI datasets can be used to predict potentially involved proteins on the basis of…

GMP Conform Protein Analysis - New Analytical Solutions, Screening Feb 2007 Scientific Paper

The success of protein based therapeutics, e.g. monoclonal antibodies, interferons, hormones etc., in the last years generated one of the fastest growing segments in the pharmaceutical industry. Furthermore, whilst some of these blockbusters drugs are already out of patent protection, an increasing number of companies enter into the field of bio-generics production. Since the withdrawal of Tysabri (Biogen Idec) from the market in 2005 and the severe side effects of Supermab recognized in a clinical phase I study in 2006, bio-therapeutics and their precise analysis on the molecular level came…

Proteomanalyse durch automatisierte Datenverarbeitung Scientific Paper

Die Automatisierung von Proteomanalysen ist von großem Interesse, allerdings hat die Vielfaltder Analysetechniken sowie die Komplexität der Analyseschritte eine allgemein verwendbareAutomatisierung bislang erschwert. Für Proteomstudien mit Hilfe von 2D-Gelen und massen-spektrometrischer Analyse gibt es inzwischen einen weitgehend standardisierten, automati-sierbaren Arbeitsablauf. Mehrere Firmenbieten komplette Geräte-Lösungen (Proteomics-Stra-ßen) oder Teillösungen an. Die elektronische Datenverarbeitung soll dabei die Aufgaben eines‚Labor Informations Management Systems‘ (LIMS) …

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