Unique class of pharmaceutical compounds
Other Formates

Other Formates

Besides antibody derived biopharmaceuticals there is an additional group of amino acid based compounds with interesting therapeutical capabilities:

Enzymes

Enzymes are proteins that act as catalysts for biochemical reactions. Enzymes have many different functions ranging covering metabolic processes, signal transduction, or translation of genetic material into proteins. Structurally, they may consist of a single unmodified protein chain up to multiple polypeptide chains with heterogeneous modifications and a distinct quaternary structure.

Protagen Protein Services (PPS) has excellent technical knowledge in the detailed characterization of enzymes with biotherapeutical potential, such as:

Alpha Galactosidase (treatment of Fabry Disease)
Pankratin
Alteplase

Growth Factors

Growth factors (or growth hormones) are proteins that are produced and secreted by particular cell types and act as growth signals on cells expressing the corresponding specific receptor, e.g. the secreting cell itself or other cell types. Functioning as "signal proteins" they regulate various intracellular processes and, on a higher level, they play a crucial role in the development of multicellular organisms. A variety of growth factors with different signal inductions are known today.

Protagen Protein Services (PPS) has excellent technical knowledge in the detailed characterization of growth factors with biotherapeutical potential, such as:

EPO
GCSF

Cytokines

Cytokines are immunoregulatory signal proteins, generated and secreted by special cell types, acting by inducing cell proliferation, apoptosis, driving cell differentiation, central for the development of the the variety of diffenret specialiued cell types of the human immune system

Protagen Protein Services (PPS) has excellent technical knowledge in the detailed characterization of growth factors with biotherapeutical potential, such as:

Interferon Alpha 2a
Interferon Beta 1a

Interferon Beta 1b
Interleukin 2
PEG Interferon alpha 2a

Coaggulation Factors

Coaggulation Factors play a central role in the highly regulated blood clothing system. Usually they are members of an exceptional cascade which ensures a fine balance between blood clotting and the fibrinolytic system to avoid blocking of blood vessels and a high risk of heart attacks. These mediators usually show a high complexity of modifications ranging from disulfide bonding, to N- and O-glycosylation, thus challenge to protein analytical techniques.

Protagen Protein Services (PPS) has excellent technical knowledge in the detailed characterization of coagulation factors such as:

FVII
FVIII

Peptide therapeutics

With the significant advancements in biologics and biopharmaceutical over the years, peptides and proteins have emerged as a major new class of therapeutics with a host of new applications in the diagnostic as well as the therapeutic sector

Peptides represent a unique class of pharmaceutical compounds, molecularly positioned between small molecules and proteins, yet biochemically and therapeutically distinct from both. As intrinsic signaling molecules for many physiological functions, peptides present an opportunity for therapeutic intervention that closely mimics natural pathways. Indeed, several peptide drugs are essentially “replacement therapies” that add back or supplement peptide hormones in cases where endogenous levels are inadequate or absent. This is exemplified by the isolation and first therapeutic use of insulin in the 1920s in diabetics who did not produce sufficient quantities of the hormone.

Protagen Protein Services (PPS) has excellent technical knowledge and long-standing experience in the detailed characterization of peptides and peptide therapeutic products such as:
 

Insulin
Glatiramer acetate
Liraglutide (
glucagon-like peptide-1 receptor agonist (GLP-1 receptor agonist)
Botulinum toxin

PPS provides a strategic approach for characterizing biopharmaceutical products. Analysis is performed in a GMP compliant laboratory using validated techniques to satisfy the latest regulatory requirements.

Protagen Protein Services (PPS) has extensive experience in analysis of different protein classes and other formates and can successfully support you with a broad range of services:

Read more to the individual analytical services here