Therapeutic antibodies are revolutionizing medical care
Antibodies

Antibodies

Since the mid-1980s, Antibodies have been developed as a new class of drugs which show a very high degree of specificity and efficacy. Today, 22 monoclonal antibodies are approved by the FDA and are applied in indications ranging from various cancer types to transplant rejection. The success of monoclonal antibodies lies in their natural ability to specifically bind only to certain targets and the high developability of this class of molecules. Protagen Protein Services (PPS) has excellent technical knowledge and long-standing experience in the detailed characterization of antibodies and antibody products

PPS has excellent technical knowledge and long-standing experience in the detailed characterization of antibodies and antibody products such as:

  • Recombinant monoclonal IgG-Type
  • Polyclonal IgG
  • Fusion proteins
  • Fc-constructs
  • Fab-fragments
  • Β-functional antibodies

Analytical support throughout the whole antibody development

PPS has extensive experience in analysis of different antibody formats and can successfully support you with:

PPS provides individual analyses or a comprehensive characterization package customised to suit your requirements and to provide data required by the regulatory authorities for antibody analysis like:

PPS provides a strategic approach for characterizing biopharmaceutical products. Analysis is performed in a GMP compliant laboratory using validated techniques to satisfy the latest regulatory requirements.

Structural characterization and confirmation

Guideline requires

Protagen Protein Services (PPS) Offers

Amino acid sequence

Amino acid composition

N- & C-terminal sequencing

Peptide mapping

S-S bridge analysis

Glycosylation analysis

Physicochemical properties

Molecular weight or size

Isoform pattern

Extinction coefficient

Electrophoretic patterns

Liquid chromatographic patterns

Spectroscopic profiles

Via Partner

 

Process and product related impurities

Guideline requires

Protagen Protein Services (PPS) Offers

Host cell proteins

Truncated forms

Post-translational modifications (PTM)

Aggregates