Dr. Thomas FladHead of Business Development
South Germany, DACH Region
Antibody Drug Conjugates (ADC) comprise a new class of anti cancer drugs. They consist of monoclonal antibodies, which are chemically linked to cytotoxic small molecule payloads such as Auristatin, Maytansinoid or other chemotherapeutic agents. Linkage can be either chemically for example through covalent coupling to amino groups of lysine residues or thiol groups of cysteine residues or even through site specific enzymatic linkage.
Quality control of ADC on the level of protein, linker, linker with payload, free payload and intact conjugate level is crucial for monitoring of production process and assessment of product safety.
Protagen Protein Services (PPS) is experienced in handling proteins and highly potent protein conjugates by combining state-of-the-art separation technologies with mass spectrometry.
Analytical support throughout ADC development
PPS has extensive experience in analysis of different formats and can successfully support you with:
PPS is continously developing new methods for ADCs and is offering services for ADC analysis like:
Protagen Protein Services (PPS) has extensive experience in analysis of different protein classes and other formates and can successfully support you with a broad range of services:
Read more to the individual analytical services here