IMG_4703For modern biopharmaceutical research, it is necessary to combine different analytical methods with each other in order to obtain a more complete assessment of the protein structure and function. The analytical methods at Protagen Protein Services GmbH include:

Mass Spectrometry

The application of mass spectrometry in protein research has revolutionized the analysis of the large and complex molecules. Protagen Protein Services GmbH is well equipped to carry out mass spectrometry analyses by MALDI-MS, LC-ESI-MS and MALDI-ISD.

Bio-IT in Mass Spectrometry

The amount of data that is produced by modern mass spectrometers has steadily increased. Completely new algorithms have been developed in order to cope with the increasing data size and complexity. Today, even though many sophisticated algorithms are available on the market, bioinformatics expertise is still needed to fully interpret mass spectrometry data sets.

Liquid Chromatography

High Performance Liquid chromatography (HPLC) encompasses a large range of methods in biopharmaceutical research such as RP-HPLC, IEX-HPLC, SEC-HPLC etc that can be applied in combination with each other as well as in combination with other analytical techniques. This makes HPLC one of the most used analytical techniques in this field, allowing separating any biomolecule from amino acids to protein complexes. The use of UPLC systems has further increased the speed and resolution of these analyses.


Electrophoretic methods have been applied to protein research for more than eighty years and allow separating proteins according to different physicochemical parameters such as charge or size. The proteins can be visualized after separation by many staining techniques, such as DIGE, silver stain, colloidal Coommassie etc.

Electrophoresis can be applied to biopharmaceutical research using SDS-PAGE, IEF, 2D PAGE or Western Blotting.

A list of instrumentation can also be found here.

All analysis of the protein, the product-related impurities and process-related impurities can be carried out according to ICH Q6B.

Your contact for Analytical Methods at Protagen Protein Services GmbH

burkhard fleckenstein

Dr. Burkhard Fleckenstein

Director Operations 
Our business development team will be happy to assist you with your project.

Phone: +49 7131 74 50 40